How we scored it
9-residue peptide (Arg, Glu, Gly, His, Lys, Phe, Pro, Trp, Val) joined by amide bonds; fermentation-derived amino acids are natural. 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Manufactured by peptide synthesis from fermentation-derived amino acids to match a fragment of human melanotropin alpha. No natural-extraction route exists at scale.
In plain English
A lab-made peptide built from 9 amino acids to mimic a small piece of a skin-signalling protein. The amino acid building blocks come from fermentation, even though the peptide itself is assembled synthetically.
CosIng definition: sh-Nonapeptide-1 is a single chain human peptide produced synthetically to be identical to a portion of the protein, Melanotropin Alpha, and contains 9 amino acids consisting of arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan and valine.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-NONAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-NONAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-NONAPEPTIDE-1