How we scored it
Six-residue peptide of Ala, Gly, Pro, Ser; no chemical cap is named; peptides = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Dominant route: solid-phase peptide synthesis from fermentation-derived L-amino acids; protecting groups and coupling agents leave no mass. Alternative: recombinant microbial expression of the same sequence gives the same value.
In plain English
A short laboratory-made peptide of six amino acids that matches a fragment of the human protein desmoglein-1, used to condition skin. It is built only from alanine, glycine, proline and serine.
CosIng definition: sh-Hexapeptide-1 is a single chain human peptide, produced synthetically to be identical to a portion of the protein, Desmoglein-1, and contains 6 amino acids consisting of alanine, glycine, proline, and serine.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-HEXAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-HEXAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-HEXAPEPTIDE-1