Database/Bleaching/sh-Decapeptide-3
100% natural origin · ISO 16128

Is sh-Decapeptide-3 natural?

Yes. Arginine, asparagine, glycine, leucine, phenylalanine, serine, tryptophan and tyrosine are fermentation or protein-hydrolysate amino acids; synthesis reagents and protecting groups leave no mass.

INCI namesh-Decapeptide-3
FunctionBleaching · Skin Protecting
FeedstockFermentation-derived or hydrolysate amino acids are assembled by…

How we scored it

10 amino-acid residues (Arg, Asn, Gly, Leu, Phe, Ser, Trp, Tyr), all natural building blocks. Any terminal amide would be about 1% of mass and is not described: 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Fermentation-derived or hydrolysate amino acids are assembled by solid-phase peptide synthesis to match a segment of human KiSS-1, and reagents leave no mass. No alternative route is commercially significant.

In plain English

A ten-amino-acid peptide made in a laboratory to match part of a human protein called KiSS-1. CosIng lists it for skin-lightening (bleaching) and skin-protecting roles. It is built from amino acids, which are generally obtained by fermentation or by breaking down proteins.

CosIng definition: sh-Decapeptide-3 is a single chain human peptide produced synthetically to be identical to a portion of the protein Metastasis-suppressor KiSS-1, and contains 10 amino acids consisting of arginine, asparagine, glycine, leucine, phenylalanine, serine, tryptophan and tyrosine. The parent protein contains a maximum of 138 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-DECAPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-DECAPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-DECAPEPTIDE-3