Database/Humectant/rh-Polypeptide-7
100% natural origin · ISO 16128

Is rh-Polypeptide-7 natural?

Yes. All atoms sit in amino acids built by a fermenting microorganism from sugar and mineral nutrients, so under the fermentation-product convention the protein is natural origin.

INCI namerh-Polypeptide-7
CAS12629-01-5
FunctionHumectant · Skin Conditioning
FeedstockDominant route: recombinant expression of the human growth…

How we scored it

Single protein chain of the 20 standard amino acids made by E. coli fermentation (recombinant human growth hormone); amino acids count as natural fermentation products; 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route: recombinant expression of the human growth hormone gene in E. coli, followed by purification. Genetically modified biotech origin may not qualify as natural under some standards, hence the review flag.

In plain English

A lab-grown version of human growth hormone, produced by bacteria (E. coli) carrying the human gene. It is used in skin-care products as a humectant and skin conditioner. It is a protein built from the 20 standard amino acids and made by fermentation.

CosIng definition: rh-Polypeptide-7 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Human Growth Hormone. It contains a maximum of 217 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2RH-POLYPEPTIDE-7. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3RH-POLYPEPTIDE-7. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=RH-POLYPEPTIDE-7