Database/Skin Conditioning/rh-Polypeptide-3
100% natural origin · ISO 16128

Is rh-Polypeptide-3 natural?

Yes. Recombinant microbial hosts assemble the protein from amino acids made from a sugar-based medium, so it counts as a fermentation-derived peptide.

INCI namerh-Polypeptide-3
CAS126469-10-1
FunctionSkin Conditioning
FeedstockDominant route is fermentation of recombinant E. coli…

How we scored it

Recombinant protein of up to 194 amino acids; residues built by E. coli or Pichia from a sugar-based medium, no non-amino-acid atoms added: fermentation and peptide rules give 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route is fermentation of recombinant E. coli or Pichia pastoris expressing the human keratinocyte growth factor gene, followed by purification. No chemical synthesis route is used.

In plain English

A recombinant version of human keratinocyte growth factor, a signalling protein, made by fermenting engineered E. coli or Pichia yeast. It is listed as a skin-conditioning ingredient. The protein is built from the 20 standard amino acids that the microbe makes from its growth medium.

CosIng definition: rh-Polypeptide-3 is a single chain recombinant human peptide, produced by fermentation in E. coli or Pichia pastoris. The starting gene is directly isolated from a human cell which codes for Keratinocyte Growth Factor. It contains a maximum of 194 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2RH-POLYPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3RH-POLYPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=RH-POLYPEPTIDE-3