Database/Skin Conditioning/rh-Polypeptide-11
100% natural origin · ISO 16128

Is rh-Polypeptide-11 natural?

Yes. The protein is biosynthesised by E. coli fermentation from sugar and nitrogen nutrients, so every residue is a natural-origin amino acid under the fermentation-product rule.

INCI namerh-Polypeptide-11
CAS62031-54-3
FunctionSkin Conditioning
FeedstockRecombinant E. coli carrying the FGF-1 gene is…

How we scored it

Recombinant protein of up to 155 standard amino acids from E. coli fermentation; every atom is amino-acid residue (cysteine S is amino-acid sulfur); no synthetic caps; 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Recombinant E. coli carrying the FGF-1 gene is grown on a glucose-based fermentation medium and the protein purified. No chemical-synthesis route is commercially significant.

In plain English

A human growth-factor protein (acidic fibroblast growth factor 1) made by genetically modified E. coli bacteria and used to condition skin. It is a protein built entirely from standard amino acids.

CosIng definition: rh-Polypeptide-11 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Acidic Fibroblast Growth Factor 1. It contains a maximum of 155 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2RH-POLYPEPTIDE-11. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3RH-POLYPEPTIDE-11. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=RH-POLYPEPTIDE-11