Database/Skin Conditioning/rh-Polypeptide-1
100% natural origin · ISO 16128

Is rh-Polypeptide-1 natural?

Yes. Amino acids built by E. coli growing on a sugar-based fermentation medium make the whole polypeptide, so no petrochemical atoms remain in the product.

INCI namerh-Polypeptide-1
FunctionSkin Conditioning · Skin Protecting
FeedstockBacteria carrying the human FGF-2 gene are fermented…

How we scored it

Recombinant protein made only of standard amino acids by E. coli fermentation; any glycosyl units are sugars. All fragments natural: 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Bacteria carrying the human FGF-2 gene are fermented on a sugar-based medium and the protein is purified. No chemical-synthesis route is used commercially.

In plain English

A human growth-factor protein (basic fibroblast growth factor) made by growing engineered E. coli bacteria on a nutrient medium and purifying the protein. It is added to skin-care products as a conditioning and protecting ingredient.

CosIng definition: rh-Polypeptide-1 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Basic Fibroblast Growth Factor. It contains a maximum of 210 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the standard amino acids. Basic Fibroblast Growth Factor; bFGF; FGF-2; Human Oligopeptide-3

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2RH-POLYPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3RH-POLYPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=RH-POLYPEPTIDE-1