Database/Skin Conditioning/Retinoxytrimethylsilane
100% petroleum · ISO 16128

Is Retinoxytrimethylsilane natural?

No. Industrial retinol is built synthetically from petrochemical ionone or citral intermediates, and the trimethylsilyl group is an organosilicon unit that the site scores as zero.

INCI nameRetinoxytrimethylsilane
CAS16729-19-4
FormulaC23H38OSi · 358.6 Da
FunctionSkin Conditioning
FeedstockSynthetic retinol is silylated with a trimethylsilyl reagent…

How we scored it

C23H38OSi 358.6 Da: retinoxy C20H29O 285.4 is synthetic retinol (0); trimethylsilyl C3H9Si 73.2 is organosilicon (0 by silicone convention); 0 / 358.6 = 0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Synthetic retinol is silylated with a trimethylsilyl reagent made from methyl chloride and silicon. Fermentation-derived retinol exists but is not significant in supply.

In plain English

Vitamin A (retinol) with its hydroxyl group capped by a trimethylsilyl group, a silicone-type unit. Used to condition skin. Retinol is made industrially by chemical synthesis, and the silyl group is a synthetic organosilicon.

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Structure

2D structure of Retinoxytrimethylsilane

[(2Z,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoxy]-trimethylsilane

PubChem CID 165362841 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Retinoxytrimethylsilane. PubChem CID 165362841. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3RETINOXYTRIMETHYLSILANE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4RETINOXYTRIMETHYLSILANE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=RETINOXYTRIMETHYLSILANE