Database/Skin Conditioning/Pyridoxal 5-Phosphate
Mostly petroleum · ISO 16128

Is Pyridoxal 5-Phosphate natural?

Mostly not. The phosphate group is mineral-derived, while the pyridine ring of vitamin B6 is chemically synthesised from petrochemical building blocks.

INCI namePyridoxal 5-Phosphate
CAS54-47-7
FormulaC8H10NO6P · 247.14 Da
FunctionSkin Conditioning
FeedstockVitamin B6 is manufactured by chemical synthesis (oxazole…

How we scored it

C8H10NO6P 247.1: phosphate HPO3 80.0 natural (mineral); pyridoxal core C8H9NO3 167.2 petrochemical (vitamin B6 is chemically synthesised). 80.0/247.1 = 0.32.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Vitamin B6 is manufactured by chemical synthesis (oxazole Diels-Alder route), oxidised to pyridoxal and phosphorylated with phosphoric acid. A fermentation route for B6 is not commercially significant.

In plain English

The active, phosphate form of vitamin B6, used to condition skin. It is made by chemically synthesising vitamin B6 and then attaching a phosphate group from phosphoric acid.

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Structure

2D structure of Pyridoxal 5-Phosphate

(4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate

PubChem CID 1051 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Pyridoxal 5-Phosphate. PubChem CID 1051. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3PYRIDOXAL 5-PHOSPHATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4PYRIDOXAL 5-PHOSPHATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PYRIDOXAL%205-PHOSPHATE