Database/Skin Conditioning/Phytonadione
100% petroleum · ISO 16128

Is Phytonadione natural?

No. Both the naphthoquinone core and the phytyl side chain are, in dominant commercial practice, built from petrochemical naphthalene and synthetic isoprenoid intermediates.

INCI namePhytonadione
CAS81818-54-4
FormulaC31H46O2 · 450.7 Da
FunctionSkin Conditioning
FeedstockVitamin K1 for pharma/cosmetic grade is made by…

How we scored it

Naphthoquinone core C11H7O2 (171 Da, petrochemical naphthalene derivative) + phytyl chain C20H39 (279.5 Da, commercially from synthetic isophytol). 0/450.7≈0.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Vitamin K1 for pharma/cosmetic grade is made by total synthesis, coupling a menadione-type naphthoquinone with synthetic isophytol. Natural chlorophyll-derived phytol exists but is not the dominant commercial feedstock.

In plain English

Phytonadione is vitamin K1, used in skincare as a conditioning ingredient. It is normally produced by industrial chemical synthesis rather than extracted from green plants, though the molecule also occurs naturally in leafy vegetables.

CosIng definition: Phytonadione is the organic compound that conforms to the formula

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Structure

2D structure of Phytonadione

2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione

PubChem CID 5284607 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Phytonadione. PubChem CID 5284607. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3PHYTONADIONE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4PHYTONADIONE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PHYTONADIONE