Database/Antioxidant/Phloretin
Route-dependent · ISO 16128

Is Phloretin natural?

It depends. Occurs naturally in apple tree bark and can be extracted, but much cosmetic-grade material is made by chemical condensation of synthetic aromatic building blocks.

INCI namePhloretin
CAS60-82-2
FormulaC15H14O5 · 274.27 Da
FunctionAntioxidant · Anti-Sebum
FeedstockDominant commercial route is believed to be chemical…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Natural extractionApple (Malus) bark/root extraction1.00~30%
Chemical synthesisAromatic condensation (phloroglucinol/hydroxybenzaldehyde types) + hydrogenation0.00~70%
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Whole-molecule route split: natural apple-bark/root extraction = 1.0; synthetic aromatic condensation (Claisen-Schmidt) plus hydrogenation = 0.0. No partial mass mixing.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant commercial route is believed to be chemical synthesis (condensation of phloroacetophenone-type and hydroxybenzaldehyde-type aromatics, then hydrogenation) for cost and purity. A natural-extraction route from apple tree bark/root also exists as a specialty ingredient.

In plain English

An antioxidant compound related to those found in apples, used in anti-ageing serums. It can be extracted from apple tree bark and roots, but much cosmetic-grade material is made by chemical synthesis.

Natural alternatives with the same function

Structure

2D structure of Phloretin

3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one

PubChem CID 4788 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Phloretin. PubChem CID 4788. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3PHLORETIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4PHLORETIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PHLORETIN