Database/Emollient/Pentapeptide-34 Trifluoroacetate
Mostly natural · ISO 16128

Is Pentapeptide-34 Trifluoroacetate natural?

Mostly. Amino acids from fermentation or hydrolysates are natural, but the trifluoroacetate counter-ion has a carbon-fluorine framework made petrochemically, so its mass counts as non-natural.

INCI namePentapeptide-34 Trifluoroacetate
FunctionEmollient · Skin Conditioning
FeedstockDominant route: solid-phase peptide synthesis from fermentation-derived amino…

How we scored it

Sequence unknown. Assume ~600 Da peptide (amino acids, natural) plus ~150 Da trifluoroacetate (1-2 CF3COO-, C-F framework, petrochemical): 600/750 = 0.80.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route: solid-phase peptide synthesis from fermentation-derived amino acids, with the peptide cleaved and purified using trifluoroacetic acid and isolated as the TFA salt. No alternative route is commercially significant.

In plain English

A short peptide made of five linked amino acids, supplied as its trifluoroacetate salt and used to condition and soften skin. The amino acids are fermentation-derived, while trifluoroacetate is a fluorinated counter-ion carried over from peptide synthesis.

CosIng definition: Pentapeptide-34 Trifluoroacetate is the trifluoroacetate salt of Pentapeptide-34

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2PENTAPEPTIDE-34 TRIFLUOROACETATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3PENTAPEPTIDE-34 TRIFLUOROACETATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PENTAPEPTIDE-34%20TRIFLUOROACETATE