Database/Skin Conditioning/Pentapeptide-3
100% natural origin · ISO 16128

Is Pentapeptide-3 natural?

Yes. Composed only of standard amino acids, which trace to fermentation or protein hydrolysis, with no petrochemical cap reported.

INCI namePentapeptide-3
CAS135679-88-8
FormulaC21H37N9O5 · 495.6 Da
FunctionSkin Conditioning
FeedstockAssembled from fermentation-derived amino acids via peptide synthesis.…

How we scored it

Peptide of Ala/Arg/Ile/Gly/Pro residues, no synthetic cap in description; amino acids are natural-origin = 1.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Assembled from fermentation-derived amino acids via peptide synthesis. No accessory petrochemical group is part of the defined structure.

In plain English

A lab-assembled chain of five amino acids used to condition skin. The amino acid building blocks typically come from fermentation.

CosIng definition: Pentapeptide-3 is a synthetic peptide containing alanine, arginine, isoleucine, glycine and proline

Structure

2D structure of Pentapeptide-3

(2S)-1-(2-aminoacetyl)-N-[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

PubChem CID 11605666 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Pentapeptide-3. PubChem CID 11605666. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3PENTAPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4PENTAPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PENTAPEPTIDE-3