How we scored it
Peptide assembled from five natural amino acids (alanine, glycine, leucine, phenylalanine, tyrosine); synthesis reagents leave no mass → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Chemically synthesized by coupling five amino acids that are themselves produced by fermentation or protein hydrolysis. Coupling and protecting reagents used during synthesis are not present in the final peptide.
In plain English
A lab-assembled chain of five amino acids (alanine, glycine, leucine, phenylalanine, tyrosine). Used in skincare for its skin-conditioning effect.
CosIng definition: Pentapeptide-18 is a synthetic peptide consisting of alanine, glycine, leucine, phenylalanine and tyrosine
Structure
(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Pentapeptide-18. PubChem CID 10099522. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3PENTAPEPTIDE-18. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4PENTAPEPTIDE-18. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PENTAPEPTIDE-18