How we scored it
Amide of palmitic acid (natural fatty acid) and a tripeptide of natural amino acids; matches Palmitoyl Pentapeptide-4 precedent. 100% natural.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Made by coupling palmitic acid, from vegetable or animal fat, to a synthetic tripeptide built from natural amino acids. Coupling reagents leave no mass in the final product.
In plain English
A skin-conditioning ingredient made by attaching a fatty acid to a small chain of three amino acids. Used in anti-ageing skincare to help support the look of skin.
CosIng definition: Palmitoyl Tripeptide-8 is the product obtained by the reaction of palmitic acid and Tripeptide-8
Structure
N-[(2S)-1-[[(2R)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]hexadecanamide
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Palmitoyl Tripeptide-8. PubChem CID 11498521. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3PALMITOYL TRIPEPTIDE-8. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4PALMITOYL TRIPEPTIDE-8. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PALMITOYL%20TRIPEPTIDE-8