How we scored it
Palmitoyl C16H31O 239.4 + Gly 57.1 + His 137.1 + Arg 156.2 + OH 17.0 = 606.8, all natural. 606.8 / 606.8 = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Palm-derived palmitic acid is coupled to the glycine of a Gly-His-Arg tripeptide built from fermentation-derived amino acids. Coupling reagents and protecting groups leave no mass in the final molecule.
In plain English
A short chain of three amino acids (glycine, histidine, arginine) with a palmitic acid tail, used for skin conditioning. The palmitic acid comes from palm oil and the amino acids from fermentation, joined in a laboratory.
CosIng definition: Palmitoyl Tripeptide-4 is the product of the reaction of palmitic acid and Tripeptide-4
Structure
(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[2-(hexadecanoylamino)acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]pentanoic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Palmitoyl Tripeptide-4. PubChem CID 172866680. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3PALMITOYL TRIPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4PALMITOYL TRIPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PALMITOYL%20TRIPEPTIDE-4