How we scored it
Palmitic acid (natural C16 fatty acid) amide-linked to Hexapeptide-12 (amino acids); condensation loses only water → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Made by acylating Hexapeptide-12 (assembled from fermentation-derived amino acids) with palmitic acid from vegetable or animal fat. No petrochemical fragments remain in the final molecule.
In plain English
A peptide (Hexapeptide-12, built from amino acids) attached to palmitic acid, a fatty acid from plant or animal fats. Used in skincare for skin conditioning.
CosIng definition: Palmitoyl Hexapeptide-12 is the product of the reaction of palmitic acid and Hexapeptide-12
Structure
2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Palmitoyl Hexapeptide-12. PubChem CID 10212452. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3PALMITOYL HEXAPEPTIDE-12. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4PALMITOYL HEXAPEPTIDE-12. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=PALMITOYL%20HEXAPEPTIDE-12