Database/Skin Conditioning/Oligopeptide-41
100% natural origin · ISO 16128

Is Oligopeptide-41 natural?

Yes. Every residue is a natural-origin L-amino acid from fermentation or protein hydrolysate, and the synthesis reagents and protecting groups leave no mass in the final peptide.

INCI nameOligopeptide-41
FormulaC63H90N18O19S · 1435.6 Da
FunctionSkin Conditioning
FeedstockDominant route is solid-phase synthesis from fermentation-derived L-amino…

How we scored it

13-residue peptide of the 11 listed amino acids, C63H90N18O19S (1435.6 Da) as the free, uncapped peptide, so all mass is amino-acid mass. 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route is solid-phase synthesis from fermentation-derived L-amino acids, the standard method for short cosmetic peptides. A recombinant or enzymatic route would give the same atom accounting.

In plain English

A short synthetic chain of 13 amino acids. It is listed as a skin-conditioning ingredient. It is built in a lab by joining amino acids, which come from fermentation or plant protein, in a set order.

CosIng definition: Oligopeptide-41 is a synthetic peptide containing 13 amino acids consisting of alanine, asparagine, glutamic acid, glycine, histidine, lysine, methionine, phenylalanine, serine, threonine and tryptophan

Structure

2D structure of Oligopeptide-41

(4S)-4-[[2-[[2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]acetyl]amino]-5-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

PubChem CID 169449958 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Oligopeptide-41. PubChem CID 169449958. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3OLIGOPEPTIDE-41. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4OLIGOPEPTIDE-41. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=OLIGOPEPTIDE-41