Database/Skin Conditioning/Octapeptide-9
100% natural origin · ISO 16128

Is Octapeptide-9 natural?

Yes. Every residue derives from fermentation- or hydrolysate-sourced amino acids, and condensation water lost on bond formation is not counted, so the whole peptide is natural origin.

INCI nameOctapeptide-9
FunctionSkin Conditioning
FeedstockAmino acids from fermentation or protein hydrolysate are…

How we scored it

Peptide of Arg, Leu, Phe, Ser, Tyr residues only, all n=1; no acetyl or acyl cap named, so 1.0. Coupling reagents and protecting groups leave no mass.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Amino acids from fermentation or protein hydrolysate are coupled by solid-phase or solution peptide synthesis. Recombinant or enzymatic assembly is an alternative and gives the same natural-origin value.

In plain English

A short chain of eight amino acids, drawn from arginine, leucine, phenylalanine, serine and tyrosine, built in a laboratory and used as a skin-conditioning ingredient. The amino acids themselves come from fermentation or from hydrolysed plant or animal protein.

CosIng definition: Octapeptide-9 is the synthetic peptide consisting of arginine, leucine, phenylalanine, serine, and tyrosine

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2OCTAPEPTIDE-9. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3OCTAPEPTIDE-9. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=OCTAPEPTIDE-9