Is Nonapeptide-9 natural?

Q: Is Nonapeptide-9 natural?

Nonapeptide-9 has a Natural Origin Index (NOI) of 1.00 (scale 0–1) per ISO 16128. A nine-residue peptide assembled from natural amino acids, with no acyl cap or other petrochemical modification noted. An NOI of 1.00 means 100% of its molecular mass is traceable to a natural, renewable source.

Yes. A nine-residue peptide assembled from natural amino acids, with no acyl cap or other petrochemical modification noted.

INCI nameNonapeptide-9

FunctionSkin Conditioning

FeedstockChemically or enzymatically assembled from amino acids of…

How we scored it

Peptide built from alanine, arginine, glutamic acid, isoleucine and leucine (all fermentation/hydrolysate amino acids); no petrochemical cap mentioned; 1.0 as for Copper Tripeptide-1.

What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Chemically or enzymatically assembled from amino acids of fermentation or protein-hydrolysate origin. 'Synthetic' refers to the assembly method, not a petrochemical feedstock.

In plain English

A lab-assembled chain of nine amino acids, used in skincare to help condition the skin.

CosIng definition: Nonapeptide-9 is a synthetic peptide consisting of alanine, arginine, glutamic acid, isoleucine, and leucine

References

1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
2NONAPEPTIDE-9. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
3NONAPEPTIDE-9. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NONAPEPTIDE-9