How we scored it
Peptide of natural amino acids only (Asp, Cys, Gly, His, Leu, Pro, Ser, Tyr plus one repeat); protecting groups and coupling reagents leave no mass. 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Dominant route is chemical peptide synthesis from protected amino acids obtained by fermentation or protein hydrolysis. No alternative route is commercially significant.
In plain English
A short chain of nine amino acids, made in a laboratory by joining amino acids together. It is used as a skin-conditioning ingredient in skin-care products. Each building block is a natural amino acid, usually produced by fermentation or from plant protein.
CosIng definition: Nonapeptide-4 is the synthetic peptide consisting of aspartic acid, cysteine, glycine, histidine, leucine, proline, serine, and tyrosine
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2NONAPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3NONAPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NONAPEPTIDE-4