Database/Hair Conditioning/Nonapeptide-1
100% natural origin · ISO 16128

Is Nonapeptide-1 natural?

Yes. Built entirely from natural, fermentation-derived amino acids; 'synthetic' describes lab assembly, not the feedstock origin.

INCI nameNonapeptide-1
CAS158563-45-2
FormulaC61H87N15O9S · 1206.5 Da
FunctionHair Conditioning · Skin Conditioning
FeedstockChemically synthesized by coupling amino acids (arginine, lysine,…

How we scored it

Peptide assembled from seven types of natural amino acids across nine residues; synthesis reagents leave no mass → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Chemically synthesized by coupling amino acids (arginine, lysine, methionine, phenylalanine, proline, tryptophan, valine) that are produced by fermentation or protein hydrolysis. Coupling reagents used leave no mass in the final peptide.

In plain English

A lab-assembled chain of nine amino acids (including arginine, lysine and tryptophan). Used in skincare and hair care for a conditioning effect.

CosIng definition: Nonapeptide-1 is a synthetic nonapeptide derived from arginine, lysine, methionine, phenylalanine, proline, tryptophan and valine

Structure

2D structure of Nonapeptide-1

(2S)-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-2-amino-4-methylsulfanylbutanoyl]pyrrolidine-2-carboxamide

PubChem CID 10418849 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Nonapeptide-1. PubChem CID 10418849. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NONAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NONAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NONAPEPTIDE-1