How we scored it
Polymethoxyflavone concentrated in citrus peel; commercial supply is peel extraction, not synthesis. All atoms citrus-derived = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Nobiletin is isolated by extraction and purification from the peel of citrus fruits such as Citrus depressa and tangerine. No petrochemical synthesis route is commercially significant.
In plain English
A natural antioxidant extracted from citrus peel, particularly Okinawan shiikuwasa and tangerine. Used in skincare to help protect skin from everyday oxidative stress.
CosIng definition: Nobiletin is the organic compound that conforms to the formula.
Structure
2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Nobiletin. PubChem CID 72344. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3NOBILETIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4NOBILETIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NOBILETIN