Database/Antimicrobial/Nisin
100% natural origin · ISO 16128

Is Nisin natural?

Yes. Produced entirely by bacterial fermentation from amino-acid building blocks; no petrochemical fragments.

INCI nameNisin
CAS1414-45-5
FormulaC143H230N42O37S7 · 3354.1 Da
FunctionAntimicrobial
FeedstockProduced by fermenting Lactococcus lactis cultures. No alternative…

How we scored it

Polypeptide from Lactococcus lactis fermentation; fermentation product built from amino acids is natural (& 2).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting Lactococcus lactis cultures. No alternative commercial route.

In plain English

A natural preservative peptide produced by fermenting a dairy bacterium. It helps control microbial growth and comes entirely from a fermentation process.

CosIng definition: Nisin is a polypeptide produced by the fermentation of Lactococcus lactis

Structure

2D structure of Nisin

6-amino-2-[2-[[2-[[2-[[2-[[2-[[7-[[6-amino-2-[[2-[[4-amino-2-[[21-[[6-amino-2-[[3-[[15-[[(Z)-2-[(2-amino-3-methylpentanoyl)amino]but-2-enoyl]amino]-12-butan-2-yl-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetrazacyclohexadecane-3-carbonyl]amino]-4-methyl-2,9,12-trioxo-5-thia-1,8,11-triazabicyclo[11.3.0]hexadecane-7-carbonyl]amino]hexanoyl]amino]-15,22-dimethyl-12-(2-methylpropyl)-9-(2-methylsulfanylethyl)-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexazacyclodocosane-3-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]-14-(1H-imidazol-5-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentazabicyclo[9.9.2]docosane-17-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoyl]amino]prop-2-enoylamino]hexanoic acid

PubChem CID 16129667 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Nisin. PubChem CID 16129667. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NISIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NISIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NISIN