Database/Antioxidant/Nicotinamide Mononucleotide
Mostly natural · ISO 16128

Is Nicotinamide Mononucleotide natural?

Mostly. The nicotinamide moiety is assumed petrochemical; the ribose sugar and phosphate group are natural.

INCI nameNicotinamide Mononucleotide
CAS1094-61-7
FormulaC11H15N2O8P · 334.22 Da
FunctionAntioxidant
FeedstockNicotinamide is predominantly synthesised from petrochemical 3-cyanopyridine, then…

How we scored it

Nicotinamide (petrochemical 3-cyanopyridine route) ~121 Da + ribose (natural sugar) ~132 Da + phosphate (mineral, natural) ~80 Da; natural 212/334 = 0.63 (approximate fragment masses).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Nicotinamide is predominantly synthesised from petrochemical 3-cyanopyridine, then combined with ribose and phosphate, which can be natural or fermentation-derived. Some suppliers now offer enzymatic/fermentation routes to the whole molecule.

In plain English

A molecule combining a vitamin-B3-related compound with a natural sugar and mineral phosphate group. Used as an antioxidant active, popular in anti-ageing serums.

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Structure

2D structure of Nicotinamide Mononucleotide

[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

PubChem CID 14180 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Nicotinamide Mononucleotide. PubChem CID 14180. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NICOTINAMIDE MONONUCLEOTIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NICOTINAMIDE MONONUCLEOTIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NICOTINAMIDE%20MONONUCLEOTIDE