Database/Skin Conditioning/Nicotinamide Adenine Dinucleotide
Mostly natural · ISO 16128

Is Nicotinamide Adenine Dinucleotide natural?

Mostly. The adenosine/ribose-phosphate portion is fermentation-derived, but the nicotinamide (vitamin B3) building block follows the calibrated petrochemical Niacinamide route.

INCI nameNicotinamide Adenine Dinucleotide
CAS53-84-9
FormulaC21H27N7O14P2 · 663.4 Da
FunctionSkin Conditioning
FeedstockManufactured biotechnologically by enzymatically joining fermentation-derived adenosine/ribose-phosphate with…

How we scored it

NAD+ C21H27N7O14P2, 663.43 Da = adenosine-diphosphate-ribose natural 542 Da (fermentation) + nicotinamide fragment petrochemical 121 Da (ex-3-cyanopyridine, per calibrated Niacinamide); 542/663 = 0.82.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured biotechnologically by enzymatically joining fermentation-derived adenosine/ribose-phosphate with nicotinamide, most of which is produced petrochemically from 3-cyanopyridine. A whole-cell fermentation/yeast-extraction route also exists but is treated here as the minor case.

In plain English

NAD+, a naturally occurring coenzyme found in every living cell, used in skin-conditioning anti-ageing products. It is manufactured biotechnologically by joining a fermentation-derived adenosine building block to a vitamin B3 building block.

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Structure

2D structure of Nicotinamide Adenine Dinucleotide

[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

PubChem CID 5892 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Nicotinamide Adenine Dinucleotide. PubChem CID 5892. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NICOTINAMIDE ADENINE DINUCLEOTIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NICOTINAMIDE ADENINE DINUCLEOTIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NICOTINAMIDE%20ADENINE%20DINUCLEOTIDE