Database/Antioxidant/Niacinamide Riboside Chloride
Mostly natural · ISO 16128

Is Niacinamide Riboside Chloride natural?

Mostly. Ribose comes from glucose fermentation and chloride from brine-derived mineral, both natural; the nicotinamide ring comes from petrochemical 3-cyanopyridine, as for niacinamide.

INCI nameNiacinamide Riboside Chloride
CAS23111-00-4
FormulaC11H15ClN2O5 · 290.70 Da
FunctionAntioxidant · Skin Protecting
FeedstockDominant route is chemical glycosylation of nicotinamide with…

How we scored it

C11H15ClN2O5 290.7 Da: ribosyl C5H9O4 133.1 + chloride 35.5 = 168.6 natural; nicotinamide C6H6N2O 122.1 petrochemical; 168.6 / 290.7 = 0.58.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route is chemical glycosylation of nicotinamide with protected D-ribose (fermentation sugar), then ion exchange to the chloride salt. Fermentation-made nicotinamide riboside exists but is not the main cosmetic supply.

In plain English

A vitamin B3 relative made of nicotinamide joined to the sugar ribose, supplied as its chloride salt. Used in skin-care products as an antioxidant and skin-protecting ingredient. It is made by chemical synthesis: ribose comes from sugar fermentation and nicotinamide from petrochemical pyridine chemistry.

CosIng definition: Niacinamide Riboside Chloride is the organic compound that conforms to the formula:

Natural alternatives with the same function

3-Glyceryl Ascorbate 100% natural origin

A stabilised, water-soluble form of vitamin C used as an antioxidant and humectant in skincare. It is made…

 Acacia Catechu Wood Extract 100% natural origin

An extract of the heartwood of the black catechu tree, rich in plant polyphenols such as catechin. It…

 Acer Palmatum Leaf Extract 100% natural origin

A plant extract from Japanese maple leaves, valued as an antioxidant. It's produced by simple extraction from the…

 Achillea Millefolium Flower Extract 100% natural origin

An extract made from yarrow flowers, a plant long used in traditional herbal preparations. Used to help condition…

 Adenosine 100% natural origin

Adenosine is a naturally occurring compound found in all living cells, playing a vital role in energy transfer…

 Aesculus Hippocastanum Extract 100% natural origin

An extract from the horse chestnut tree, used to soothe and protect skin and tighten its surface feel.…

Structure

2D structure of Niacinamide Riboside Chloride

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide chloride

PubChem CID 90480033 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Niacinamide Riboside Chloride. PubChem CID 90480033. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NIACINAMIDE RIBOSIDE CHLORIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NIACINAMIDE RIBOSIDE CHLORIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NIACINAMIDE%20RIBOSIDE%20CHLORIDE