Database/Skin Conditioning/Neohesperidin
100% natural origin · ISO 16128

Is Neohesperidin natural?

Yes. Glycoside isolated from citrus peel (bitter orange); sugar and flavonoid fragments both plant-derived.

INCI nameNeohesperidin
CAS13241-33-3
FormulaC28H34O15 · 610.6 Da
FunctionSkin Conditioning
FeedstockIsolated by extraction from the peel of bitter…

How we scored it

Citrus flavanone glycoside; commercially extracted from bitter-orange peel, not synthesised. Natural sugar plus flavonoid fragment = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Isolated by extraction from the peel of bitter (Seville) orange, Citrus aurantium. It is not commercially produced by chemical synthesis.

In plain English

A natural flavonoid extracted from bitter orange peel, used in skincare for its antioxidant properties. Comes directly from the citrus fruit, not synthesised.

Structure

2D structure of Neohesperidin

(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one

PubChem CID 442439 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Neohesperidin. PubChem CID 442439. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NEOHESPERIDIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NEOHESPERIDIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NEOHESPERIDIN