How we scored it
GHK part C14H21N6O4 337.4 Da (glycine, histidine, lysine; n=1) + Mn 54.9 Da (mineral ion; n=1) = 392.3/392.3 = 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Dominant route is chemical peptide synthesis from protected amino acids obtained by fermentation or protein hydrolysis, followed by complexation with a manganese salt. No alternative route is commercially significant.
In plain English
A small peptide of three amino acids (glycine, histidine and lysine) bound to manganese. It is used as a skin-conditioning ingredient in skin-care products. The peptide is assembled in a laboratory from amino acids, and the manganese is a naturally occurring mineral.
CosIng definition: Glycine, synthetic tripeptide with histidine and lysine, manganese complex
Structure
(2S)-6-amino-2-[[(2S)-2-(2-azanidylacetyl)azanidyl-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoate;manganese(3+)
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Manganese Tripeptide-1. PubChem CID 169450580. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3MANGANESE TRIPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4MANGANESE TRIPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=MANGANESE%20TRIPEPTIDE-1