Database/Antioxidant/Manganese Glycinate
Route-dependent · ISO 16128

Is Manganese Glycinate natural?

It depends. The manganese counter-ion is mineral; whether the glycine half is natural depends on the supplier's glycine source.

INCI nameManganese Glycinate
CAS14281-77-7
FormulaC4H8MnN2O4 · 203.06 Da
FunctionAntioxidant · Skin Conditioning
Feedstockmanganese salt of glycine (fermentation or synthetic).

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
natural-origin glycineglycine from fermentation or protein hydrolysis chelated with manganese (mineral)1.00minorityevery atom natural or mineral origin
synthetic glycineglycine from chloroacetic acid + ammonia (petrochemical) chelated with manganese (mineral)0.27majorityonly the manganese 54.9 Da of 203.1 Da is natural origin; 54.9/203.1 = 0.27
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Glycine is route-dependent on this site (see Glycine). Manganese glycinate 203.1 Da = manganese 54.9 Da (mineral, natural) + two glycinate residues (route-dependent). Natural glycine: 1.0; synthetic glycine: 54.9/203.1 = 0.27.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

manganese salt of glycine (fermentation or synthetic).

In plain English

A manganese salt of the amino acid glycine. Supplies manganese, a trace mineral, and has antioxidant properties in skincare.

CosIng definition: Manganese Glycinate is the manganese salt of glycine that conforms to the formula.

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Structure

2D structure of Manganese Glycinate

bis(2-aminoacetate);manganese(2+)

PubChem CID 151440 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Manganese Glycinate. PubChem CID 151440. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3MANGANESE GLYCINATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4MANGANESE GLYCINATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=MANGANESE%20GLYCINATE