Database/Skin Conditioning/Isooctanoyl Tetrapeptide-25
Mostly natural · ISO 16128

Is Isooctanoyl Tetrapeptide-25 natural?

Mostly. The four amino acids come from fermentation or protein hydrolysis (natural), while the branched octanoyl cap is made by oxo chemistry from propylene (petrochemical).

INCI nameIsooctanoyl Tetrapeptide-25
FunctionSkin Conditioning
FeedstockDominant route: solid-phase peptide synthesis from fermentation-derived amino…

How we scored it

Sequence not given; assume tetrapeptide ~450 Da (449 natural) + isooctanoyl C8H15O 127 Da petrochemical. 449/(449+127) = 0.78.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route: solid-phase peptide synthesis from fermentation-derived amino acids, then acylation with petrochemical branched octanoic acid (2-ethylhexanoic or isooctanoic acid). No natural-origin route for the branched acid is commercial.

In plain English

A short chain of four amino acids with a branched eight-carbon fatty acid attached, used to condition skin. The peptide part is built from amino acids that come from fermentation or protein hydrolysis; the fatty acid tail is made from petrochemical feedstock.

CosIng definition: Isooctanoyl Tetrapeptide-25 is the product obtained by the reaction of Tetrapeptide-25 with a branched chain octanoic acid.

Natural alternatives with the same function

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ISOOCTANOYL TETRAPEPTIDE-25. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ISOOCTANOYL TETRAPEPTIDE-25. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ISOOCTANOYL%20TETRAPEPTIDE-25