Database/Skin Conditioning/Hyaluronidase
100% natural origin · ISO 16128

Is Hyaluronidase natural?

Yes. A protein made only of amino acids from animal tissue or fermentation, so every atom is natural-origin.

INCI nameHyaluronidase
CAS37326-33-3
FunctionSkin Conditioning
FeedstockTraditionally extracted from bovine or ovine testes and…

How we scored it

Enzyme protein built only from amino acids (animal-tissue extract or recombinant fermentation); no synthetic fragments = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Traditionally extracted from bovine or ovine testes and purified; recombinant forms are produced in cultured cells or microbes. Both routes give a natural-origin protein.

In plain English

An enzyme that breaks down hyaluronic acid, listed for skin conditioning. It is a protein, obtained from animal tissue or made by microbial or cell-culture fermentation.

CosIng definition: Hyaluronidase is the enzyme which catalyses hydrolysis of the glycosidic linkage of hyaluronic acid

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2HYALURONIDASE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3HYALURONIDASE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HYALURONIDASE