Database/Humectant/Human Fibroblast Conditioned Media
Mostly natural · ISO 16128

Is Human Fibroblast Conditioned Media natural?

Mostly. Aqueous cell-culture supernatant: water, amino acids, salts, glucose and secreted human proteins are natural; only trace synthetic indicator/buffer is petrochemical.

INCI nameHuman Fibroblast Conditioned Media
FunctionHumectant · Skin Conditioning
FeedstockProduced by culturing human dermal fibroblasts in DMEM…

How we scored it

Predominantly water (natural) plus DMEM solutes (amino acids, glucose, mineral salts, all natural) and fibroblast-secreted proteins (natural); minor synthetic dye/buffer traces (<5%). Est. 0.97.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by culturing human dermal fibroblasts in DMEM (or CSG) base media, optionally with fetal bovine serum, then harvesting the spent media. No single dominant alternative route; formulation varies by supplier.

In plain English

The nutrient liquid left over after growing human skin cells in the lab, containing proteins the cells released; used as a moisturising ingredient.

CosIng definition: Human Fibroblast Conditioned Media is the growth media removed from cultures of human fibroblasts after several days of growth. The starting media is CSG or Dulbecco's Modified Eagle Medium, and may or may not contain fetal bovine serum

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2HUMAN FIBROBLAST CONDITIONED MEDIA. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3HUMAN FIBROBLAST CONDITIONED MEDIA. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HUMAN%20FIBROBLAST%20CONDITIONED%20MEDIA