Database/Antimicrobial/Hexetidine
100% petroleum · ISO 16128

Is Hexetidine natural?

No. Entire structure is a synthetic heterocyclic amine built from petrochemical formaldehyde and 2-ethylhexanol-derived alkyl groups.

INCI nameHexetidine
CAS141-94-6
FormulaC21H45N3 · 339.6 Da
FunctionAntimicrobial · Oral Care
FeedstockManufactured by reacting formaldehyde, methylamine and 2-ethylhexylamine, all…

How we scored it

Fully synthetic diazinane ring built from formaldehyde, methylamine and 2-ethylhexyl groups (petrochemical); no natural fragments. 0.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by reacting formaldehyde, methylamine and 2-ethylhexylamine, all petrochemical, to build the hexahydropyrimidine ring. There is no natural-origin production route for this synthetic antimicrobial.

In plain English

A fully synthetic antimicrobial compound used in mouthwashes and oral care products to control bacteria, built entirely from petrochemical building blocks in a laboratory process.

CosIng definition: Hexetidine is the heterocyclic organic compound that conforms to the formula:

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Structure

2D structure of Hexetidine

1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine

PubChem CID 3607 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hexetidine. PubChem CID 3607. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HEXETIDINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HEXETIDINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXETIDINE