Database/Skin Conditioning/Hexapeptide-9
100% natural origin · ISO 16128

Is Hexapeptide-9 natural?

Yes. Built from natural amino-acid building blocks; peptide bond formation leaves no petrochemical mass.

INCI nameHexapeptide-9
CAS885024-94-2
FormulaC24H38N8O9 · 582.6 Da
FunctionSkin Conditioning
FeedstockSynthesized from glutamine, glycine and proline, amino acids…

How we scored it

6-residue peptide (glutamine, glycine, proline); amino acids natural = 1.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Synthesized from glutamine, glycine and proline, amino acids obtained by fermentation or protein hydrolysis. No petrochemical mass remains in the assembled peptide.

In plain English

A small chain of six amino acids assembled in a lab from natural amino-acid building blocks. Used in skin care as a conditioning ingredient.

CosIng definition: Hexapeptide-9 is a synthetic peptide containing Glutamine, Glycine and Proline residues

Structure

2D structure of Hexapeptide-9

(2S)-5-amino-2-[[(2S)-1-[2-[[(2S)-5-amino-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid

PubChem CID 16129319 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hexapeptide-9. PubChem CID 16129319. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HEXAPEPTIDE-9. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HEXAPEPTIDE-9. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXAPEPTIDE-9