Database/Skin Conditioning/Hexapeptide-8
100% natural origin · ISO 16128

Is Hexapeptide-8 natural?

Yes. Built solely from natural amino acids; the synthesis reagents used to join them leave no residual mass.

INCI nameHexapeptide-8
CAS304432-12-0
FormulaC32H57N13O12S · 847.9 Da
FunctionSkin Conditioning
FeedstockManufactured by chemically joining amino acids from fermentation…

How we scored it

Peptide of arginine, glutamic acid, glutamine and methionine; amino acids are fermentation-derived, coupling reagents leave no mass = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by chemically joining amino acids from fermentation or protein hydrolysis into a short peptide chain. No petrochemical fragment remains in the final molecule.

In plain English

A lab-assembled short chain of natural amino acids, used in anti-ageing skincare to help condition skin. The amino acid building blocks come from fermentation, like many other skincare peptides.

CosIng definition: Hexapeptide-8 is a synthetic peptide containing arginine, glutamic acid, glutamine and methionine.

Structure

2D structure of Hexapeptide-8

(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

PubChem CID 9919047 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hexapeptide-8. PubChem CID 9919047. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HEXAPEPTIDE-8. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HEXAPEPTIDE-8. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXAPEPTIDE-8