How we scored it
C25H46N10O8S, 646.8 Da, fits Ile-Gln-Ala-Cys-Arg-Gly (one cysteine; description says cystine); six amino acids joined by amide bonds, cysteine sulfur included, no caps. 646.8 / 646.8 = 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Fermentation-derived amino acids are assembled by chemical peptide synthesis; protecting groups and coupling agents leave no mass. No petrochemical fragment remains.
In plain English
A short chain of six amino acids (isoleucine, glutamine, alanine, cysteine, arginine, glycine) used as a skin-conditioning ingredient in serums. It is assembled in the lab from amino acids that are made by fermentation.
CosIng definition: Hexapeptide-42 is the synthetic peptide consisting of alanine, arginine, cystine, glutamine, glycine, and isoleucine.
Structure
2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Hexapeptide-42. PubChem CID 9961072. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3HEXAPEPTIDE-42. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4HEXAPEPTIDE-42. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXAPEPTIDE-42