Database/Skin Conditioning/Hexapeptide-12
100% natural origin · ISO 16128

Is Hexapeptide-12 natural?

Yes. All four residues are fermentation or hydrolysate amino acids assembled by peptide bond formation.

INCI nameHexapeptide-12
CAS70592-18-6
FormulaC22H38N6O7 · 498.6 Da
FunctionSkin Conditioning
FeedstockBuilt by solid-phase synthesis from fermentation-derived amino acids…

How we scored it

Synthetic peptide of alanine, glycine, proline, valine; all amino-acid fragments, condensation water not petroleum mass → 1.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built by solid-phase synthesis from fermentation-derived amino acids (alanine, glycine, proline, valine). No petrochemical building blocks are involved.

In plain English

A short lab-made chain of amino acids used to condition skin. The individual amino acids come from fermentation, the same process used to make foods like yogurt.

CosIng definition: Hexapeptide-12 is a synthetic peptide containing Alanine, Glycine, Proline and Valine residues

Structure

2D structure of Hexapeptide-12

(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoic acid

PubChem CID 10097423 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hexapeptide-12. PubChem CID 10097423. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HEXAPEPTIDE-12. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HEXAPEPTIDE-12. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXAPEPTIDE-12