Database/Anti-Seborrheic/Hexamidine Diisethionate
100% petroleum · ISO 16128

Is Hexamidine Diisethionate natural?

No. Aromatic diamidine core is synthesized from petrochemical benzonitrile derivatives; isethionate counter-ions come from petrochemical ethylene oxide.

INCI nameHexamidine Diisethionate
CAS659-40-5
FormulaC24H38N4O10S2 · 606.7 Da
FunctionAnti-Seborrheic · Antimicrobial
FeedstockManufactured by multi-step organic synthesis from 4-hydroxybenzonitrile and…

How we scored it

Hexamidine (aromatic bis-amidine, benzene-derived) 354.46 Da + 2x isethionate (from ethylene oxide + sulfite) 252.26 Da; both fragments petrochemical = 0/606.7 = 0.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by multi-step organic synthesis from 4-hydroxybenzonitrile and dibromohexane, salified with isethionic acid from ethylene oxide and sodium bisulfite. No natural route.

In plain English

A synthetic antimicrobial and preservative ingredient that helps control microbial growth and manage oiliness in formulas.

CosIng definition: Hexamidine Diisethionate is the organic salt that conforms to the formula:

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Structure

2D structure of Hexamidine Diisethionate

4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(2-hydroxyethanesulfonic acid)

PubChem CID 3080571 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hexamidine Diisethionate. PubChem CID 3080571. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HEXAMIDINE DIISETHIONATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HEXAMIDINE DIISETHIONATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HEXAMIDINE%20DIISETHIONATE