Database/Antioxidant/Hesperidin Methyl Chalcone
Mostly natural · ISO 16128

Is Hesperidin Methyl Chalcone natural?

Mostly. Built almost entirely from natural hesperidin extracted from citrus; only the added methyl group traces to a petrochemical methylating agent.

INCI nameHesperidin Methyl Chalcone
CAS24292-52-2
FormulaC29H36O15 · 624.6 Da
FunctionAntioxidant
FeedstockManufactured from hesperidin extracted from citrus peel, converted…

How we scored it

Hesperidin (natural citrus flavonoid glycoside) C28H34O15 610 Da + petrochemical methyl group (from methylation reagent) 14 Da; chalcone ring-opening adds no atoms. 610/624 = 0.98.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured from hesperidin extracted from citrus peel, converted to its chalcone form and methylated with a petrochemical methylating agent. The citrus-derived flavonoid dominates the molecule's mass.

In plain English

A modified form of hesperidin, a natural compound from citrus fruit, with one small chemical group added during processing. Used as an antioxidant, often in products targeting redness or dark circles.

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Structure

2D structure of Hesperidin Methyl Chalcone

(E)-3-(3-hydroxy-4-methoxyphenyl)-1-[2-hydroxy-6-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxyphenyl]prop-2-en-1-one

PubChem CID 6436550 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Hesperidin Methyl Chalcone. PubChem CID 6436550. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3HESPERIDIN METHYL CHALCONE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4HESPERIDIN METHYL CHALCONE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HESPERIDIN%20METHYL%20CHALCONE