Database/Skin Conditioning/Glycyrrhetinic Acid
100% natural origin · ISO 16128

Is Glycyrrhetinic Acid natural?

Yes. Hydrolysis product of glycyrrhizin, itself extracted from licorice root; entirely plant-triterpenoid carbon skeleton.

INCI nameGlycyrrhetinic Acid
CAS471-53-4
FormulaC30H46O4 · 470.7 Da
FunctionSkin Conditioning
FeedstockGlycyrrhetinic Acid is produced by hydrolysing glycyrrhizin extracted…

How we scored it

Triterpenoid obtained by acid/enzymatic hydrolysis of glycyrrhizin extracted from licorice root; extraction-hydrolysis convention = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Glycyrrhetinic Acid is produced by hydrolysing glycyrrhizin extracted from licorice (Glycyrrhiza glabra) root. This extraction-and-hydrolysis route is the standard commercial process.

In plain English

A compound derived from licorice root, used in skincare to condition and help calm the appearance of sensitive skin.

Structure

2D structure of Glycyrrhetinic Acid

(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

PubChem CID 10114 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Glycyrrhetinic Acid. PubChem CID 10114. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3GLYCYRRHETINIC ACID. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4GLYCYRRHETINIC ACID. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=GLYCYRRHETINIC%20ACID