Database/Skin Conditioning/Ethyl Butylacetylaminopropionate
100% petroleum · ISO 16128

Is Ethyl Butylacetylaminopropionate natural?

No. Butylamine, ethyl acrylate (supplying the beta-alanine skeleton and ethyl ester) and the acetyl cap from acetic anhydride are all petrochemical, so no atoms are natural-origin.

INCI nameEthyl Butylacetylaminopropionate
CAS52304-36-6
FormulaC11H21NO3 · 215.29 Da
FunctionSkin Conditioning · Cleansing Surfactant
FeedstockMade by aza-Michael addition of n-butylamine to ethyl…

How we scored it

C11H21NO3 215 Da: N-butyl (butylamine), beta-alanine backbone with ethyl ester (ethyl acrylate) and N-acetyl cap (acetic anhydride) are all petrochemical. Natural mass 0 Da; 0/215 = 0.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by aza-Michael addition of n-butylamine to ethyl acrylate followed by N-acetylation with acetic anhydride, all from petrochemical sources. A route from bio-based beta-alanine, ethanol and butanol is conceivable but not commercially significant.

In plain English

A synthetic ingredient best known as the insect repellent IR3535, also listed as a skin conditioner. It is built from butylamine, an acrylate ester and an acetyl group, all produced from petrochemicals.

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Structure

2D structure of Ethyl Butylacetylaminopropionate

ethyl 3-[acetyl(butyl)amino]propanoate

PubChem CID 104150 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Ethyl Butylacetylaminopropionate. PubChem CID 104150. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ETHYL BUTYLACETYLAMINOPROPIONATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ETHYL BUTYLACETYLAMINOPROPIONATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ETHYL%20BUTYLACETYLAMINOPROPIONATE