Database/Skin Conditioning/Esculetin
Route-dependent · ISO 16128

Is Esculetin natural?

It depends. Plant-extracted/hydrolysed esculetin is fully natural; petrochemical-phenol-based synthesis gives 0.0, and commercial supply is mixed.

INCI nameEsculetin
CAS305-01-1
FormulaC9H6O4 · 178.14 Da
FunctionSkin Conditioning
FeedstockEsculetin occurs naturally in horse-chestnut and ash bark,…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Plant extraction / esculin hydrolysisAesculus/Fraxinus bark glycoside (esculin)1.00minor
Pechmann condensation synthesisresorcinol (petrochemical phenol)0.00likely dominant, unconfirmed
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Natural route: extraction/hydrolysis of esculin from bark = 1.0. Synthetic route: Pechmann condensation from resorcinol (petrochemical phenol) = 0.0. Dominant commercial route uncertain, likely synthesis. Headline shows the best route (1.00), as for every route-dependent entry on the site.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Esculetin occurs naturally in horse-chestnut and ash bark, obtainable by extraction or esculin hydrolysis, but is also manufactured by Pechmann condensation from resorcinol, a petrochemical phenol derivative. Market share between the two routes could not be confirmed.

In plain English

A plant compound found in horse-chestnut and ash bark, used to help condition skin. It can be extracted from plants or made synthetically from petroleum-derived chemicals; both methods are used commercially.

Natural alternatives with the same function

Structure

2D structure of Esculetin

6,7-dihydroxychromen-2-one

PubChem CID 5281416 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Esculetin. PubChem CID 5281416. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ESCULETIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ESCULETIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ESCULETIN