Database/Antimicrobial/Domiphen Bromide
Mostly natural · ISO 16128

Is Domiphen Bromide natural?

Mostly. The lauryl chain and bromide are natural-origin; the phenoxyethyl and N-methyl groups trace to phenol, ethylene oxide and methylation reagents.

INCI nameDomiphen Bromide
CAS538-71-6
FormulaC22H40BrNO · 414.5 Da
FunctionAntimicrobial · Antiplaque
FeedstockMade by quaternising lauryl (coconut/palm-kernel) dimethylamine with 2-bromoethyl…

How we scored it

Dodecyl+N (lauryl, oleochemical) 183 Da + Br- counter-ion 80 Da = 263 natural; vs 2 N-methyl (30 Da) + phenoxyethyl (phenol+ethylene oxide, 121 Da) = 151 petrochemical. 263/414=0.64.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by quaternising lauryl (coconut/palm-kernel) dimethylamine with 2-bromoethyl phenyl ether, itself from petrochemical phenol and ethylene oxide. Bromide is treated as a natural mineral counter-ion.

In plain English

An antimicrobial ingredient built from a coconut-derived fatty chain joined to a synthetic phenol-based group. Roughly two-thirds of its weight traces to coconut/palm sources.

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Structure

2D structure of Domiphen Bromide

dodecyl-dimethyl-(2-phenoxyethyl)azanium bromide

PubChem CID 10866 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Domiphen Bromide. PubChem CID 10866. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3DOMIPHEN BROMIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4DOMIPHEN BROMIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DOMIPHEN%20BROMIDE