Database/Skin Conditioning/Disodium Phosphocreatine
Mostly petroleum · ISO 16128

Is Disodium Phosphocreatine natural?

Mostly not. Sodium and the phosphoryl group are mineral, but the creatine residue is industrially synthesised from sarcosinate and cyanamide, so it counts as petrochemical.

INCI nameDisodium Phosphocreatine
CAS922-32-7
FormulaC4H8N3Na2O5P · 255.08 Da
FunctionSkin Conditioning
FeedstockDominant route phosphorylates synthetic creatine (from sodium sarcosinate…

How we scored it

Na2 45.98 + PO3 78.97 = 124.95 mineral; creatine residue C4H8N3O2 130.13 synthetic (sarcosinate + cyanamide). 124.95/255.08 = 0.49.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route phosphorylates synthetic creatine (from sodium sarcosinate and cyanamide) with a phosphorus reagent and converts it to the disodium salt. Enzymatic phosphorylation with ATP also starts from synthetic creatine.

In plain English

A sodium salt of phosphocreatine, the molecule muscle cells use to store energy, added to products for skin conditioning. The creatine part is made synthetically and combined with phosphate and sodium minerals.

CosIng definition: Disodium Phosphocreatine is the organic compound

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Structure

2D structure of Disodium Phosphocreatine

disodium;2-[methyl-[(E)-N'-phosphonatocarbamimidoyl]amino]acetic acid

PubChem CID 9571077 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Disodium Phosphocreatine. PubChem CID 9571077. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3DISODIUM PHOSPHOCREATINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4DISODIUM PHOSPHOCREATINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DISODIUM%20PHOSPHOCREATINE