Database/Skin Conditioning/Disodium Glycyrrhizate
100% natural origin · ISO 16128

Is Disodium Glycyrrhizate natural?

Yes. Neutralised licorice-root glycyrrhizic acid with sodium hydroxide; both the acid and the sodium counter-ion are natural-origin.

INCI nameDisodium Glycyrrhizate
CAS71277-79-7
FormulaC42H59Na2O16- · 865.9 Da
FunctionSkin Conditioning
FeedstockProduced by extracting glycyrrhizic acid from licorice (Glycyrrhiza…

How we scored it

Disodium salt of glycyrrhizic acid (licorice triterpene glycoside); Na counter-ions natural-origin, whole molecule 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by extracting glycyrrhizic acid from licorice (Glycyrrhiza glabra) root and neutralising it with sodium hydroxide to form the disodium salt. No petrochemical route is used.

In plain English

A soothing ingredient made by extracting a natural compound from licorice root and converting it into a water-soluble salt. It is used to condition and calm the skin.

Structure

2D structure of Disodium Glycyrrhizate

disodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate

PubChem CID 118984432 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Disodium Glycyrrhizate. PubChem CID 118984432. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3DISODIUM GLYCYRRHIZATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4DISODIUM GLYCYRRHIZATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DISODIUM%20GLYCYRRHIZATE