How we scored it
Synthetic dipeptide of proline and hydroxyproline; both natural-origin fermentation/hydrolysate amino acids, so fully natural.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Made by peptide synthesis from proline and hydroxyproline, both produced by fermentation or protein hydrolysis. No petrochemical fragment remains.
In plain English
A lab-made two-amino-acid peptide used to condition skin, built from proline and hydroxyproline, both of which come from fermentation or protein hydrolysis rather than petroleum.
CosIng definition: Dipeptide-6 is the synthetic peptide consisting of proline and hydroxyproline
Structure
(2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Dipeptide-6. PubChem CID 11902893. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3DIPEPTIDE-6. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4DIPEPTIDE-6. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DIPEPTIDE-6