Database/Skin Conditioning/Dipeptide-2
100% natural origin · ISO 16128

Is Dipeptide-2 natural?

Yes. Built entirely from two natural amino acids (valine, tryptophan) joined by a peptide bond.

INCI nameDipeptide-2
CAS24587-37-9
FormulaC16H21N3O3 · 303.36 Da
FunctionSkin Conditioning
FeedstockSynthesized by coupling the amino acids valine and…

How we scored it

Dipeptide of valine + tryptophan, both fermentation/hydrolysate amino acids; peptide bond formation loses only water → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Synthesized by coupling the amino acids valine and tryptophan, which are commercially produced by fermentation or protein hydrolysis. The coupling reagents used leave no atoms in the final dipeptide.

In plain English

A small peptide built from two amino acids, valine and tryptophan. Used in skincare for its skin-conditioning effect.

CosIng definition: Dipeptide-2 is the dipeptide composed of valine and tryptophan

Structure

2D structure of Dipeptide-2

(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoic acid

PubChem CID 168182 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Dipeptide-2. PubChem CID 168182. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3DIPEPTIDE-2. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4DIPEPTIDE-2. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DIPEPTIDE-2