Database/Skin Conditioning/Decapeptide-4
100% natural origin · ISO 16128

Is Decapeptide-4 natural?

Yes. All atoms trace to fermentation-derived amino acids; peptide-bond assembly loses only water.

INCI nameDecapeptide-4
CAS2227218-71-3
FormulaC53H88N16O16S3 · 1301.6 Da
FunctionSkin Conditioning
FeedstockDecapeptide-4 is solid-phase synthesised from the seven listed…

How we scored it

Peptide from Arg,Asp,Cys,Glu,Leu,Met,Tyr (formula C53H88N16O16S3 confirms amino-acid/amide composition); condensation water lost only → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Decapeptide-4 is solid-phase synthesised from the seven listed amino acids, standard fermentation/hydrolysate commodities. No petrochemical route is used.

In plain English

A synthetic chain of seven natural amino acids used to help condition skin. It is built in a lab by joining amino acids that themselves come from fermentation.

CosIng definition: Decapeptide-4 is a synthetic peptide consisting of arginine, aspartic acid, cysteine, glutamic acid, leucine, methionine and tyrosine

Structure

2D structure of Decapeptide-4

(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

PubChem CID 176195042 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Decapeptide-4. PubChem CID 176195042. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3DECAPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4DECAPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=DECAPEPTIDE-4