Database/Skin Conditioning/Cyanocobalamin
100% natural origin · ISO 16128

Is Cyanocobalamin natural?

Yes. Produced by Pseudomonas or Propionibacterium fermentation; the complex cobalt-corrin structure is a fermentation product, and cobalt is a natural mineral.

INCI nameCyanocobalamin
CAS68-19-9
FormulaC63H88CoN14O14P · 1355.4 Da
FunctionSkin Conditioning
FeedstockManufactured by large-scale bacterial fermentation, then purified and…

How we scored it

Vitamin B12; corrin ring, nucleotide and cobalt assembled entirely by microbial fermentation. 100% natural mass.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by large-scale bacterial fermentation, then purified and stabilised as the cyanide complex. This is the dominant commercial route worldwide.

In plain English

Cyanocobalamin is vitamin B12, used in skincare to condition the skin. It's produced by fermenting bacteria in large tanks, the same way it's made in nature, then purified.

Structure

2D structure of Cyanocobalamin

PubChem CID 166596686 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Cyanocobalamin. PubChem CID 166596686. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CYANOCOBALAMIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CYANOCOBALAMIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CYANOCOBALAMIN